Myosin IIB knockout fibroblasts typically show multiple protruding edges and branches. These cells fail to coordinate frontal protrusion and tail retraction for directional movements. Instead, tips of protrusion often "walk" away from the rest of the cell to form cytoplasmic fragments. Some fragments remain tethered to the cell through invisible strands (above the cell), others appear to be totally detached (near the top edge). Recording time, 91 min. |