CMU MEMS Laboratory Publication Abstract


in The 13th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), pp. 1280-1283, June 5-9, 2005, Seoul, Korea.
System-Oriented Modeling and Simulation of Biofluidic Lab-on-a-Chip
Y. Wang, R. Magargle, Q. Lin, J. Hoburg and T. Mukherjee
This paper presents a schematic-based and system-oriented modeling and simulation framework to enable top-down designs of multi-functional biofluidic lab-on-a-chip systems. An analog hardware description language (Verilog-A) is used to integrate parameterized and closed-form models of elements with different functionalities (e.g., mixing, reaction, injection and separation). Both DC and transient analysis are performed on a practical competitive immunoassay chip to capture the influence of topology, element sizes, material properties and operational parameters on the chip performance. Accuracy (relative error generally less than 5%) and speedup (>100x) of the schematic-based simulation is obtained by comparison to continuum numerical simulation as well as experimental measurements. A redesign of the original LoC device using our framework to improve bio-analysis efficiency and minimize chip-area has been demonstrated.
© 2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Full paper (PDF) (opens in new window).

This page was generated in 0.012178 seconds at 02:15:08 am EST on 19 Jan 2018.

overview | projects | people | publications | intranet | resources         © 1998-2009  Carnegie Mellon