CMU MEMS Laboratory Publication Abstract

 

	in The 13th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), pp. 1280-1283, June 5-9, 2005, Seoul, Korea.
	System-Oriented Modeling and Simulation of Biofluidic Lab-on-a-Chip
	Y. Wang, R. Magargle, Q. Lin, J. Hoburg and T. Mukherjee ABSTRACT:
	This paper presents a schematic-based and system-oriented modeling and simulation framework to enable top-down designs of multi-functional biofluidic lab-on-a-chip systems. An analog hardware description language (Verilog-A) is used to integrate parameterized and closed-form models of elements with different functionalities (e.g., mixing, reaction, injection and separation). Both DC and transient analysis are performed on a practical competitive immunoassay chip to capture the influence of topology, element sizes, material properties and operational parameters on the chip performance. Accuracy (relative error generally less than 5%) and speedup (>100x) of the schematic-based simulation is obtained by comparison to continuum numerical simulation as well as experimental measurements. A redesign of the original LoC device using our framework to improve bio-analysis efficiency and minimize chip-area has been demonstrated.
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